Cardiotonic Drugs from the Avicenna’s Point of View

Despite the widespread use of chemical agents in the field of cardiovascular diseases, today, universal approach is towards natural remedies. Old medical schools are important sources of natural medicines and one of the most impressive ancient scientists is Avicenna (980-1037 AD). Avicenna not only devoted a chapter of Canon to heart diseases and their treatment but also wrote a treatise on cardiac drugs. The name of this essay is "Al-Resaleh fi Al-Adviyah Al-ghalbyah" which includes multiple simple cardiotonics such as Rose (Rosa damascena L.) and amla (Emblica officinalis Gaertn.) (1). Rose is a cardiotonic drug due to its fragrance and astringency power (1). Two cardiotonic products of rose are rose water and sugary "goleghand" (an electuary that is made of rose petals and sugar) (2). On the other hand, recent studies demonstrated that rose has inotropic effect (3), and recovers cardiovascular function (4). Amla is a cardiotonic drug because of being astringent and strengthening the cardiac mass. It has been shown that amla can improve contractile function and tissue anti-oxidant status (5) and protect rat hearts from oxi-dative stress (6). Avicenna's definition of cardiotonic is comparable in part to its modern definition, however, encompasses more details. According to Canon, astrin-gency power ("ghabz"), being fragrant, and desiccation ("tajfif") or drying redundant moistures are the most important traditional mechanisms of action of cardiotonics (2). Additionally, some drugs such as cinnamon, pista-chio, and camphor have an inherent individual property, which is named as "theriaqiyat" (being antidote). The action of antidote drugs is related to reinforcement of the nature ("tabiat") (2). "Theriaqiyat" may be considered as an analogous to antioxidative property; because, the drugs with these two properties can eliminate the harmful effects of toxins. Moreover, astringency power may be matching to myocardial contractility in some simple drugs. However, research that is more extensive is needed to confirm these theories. We can rationalize the effectiveness of traditional cardiotonics in treatment of heart diseases by means of previously mentioned mechanisms. For example, a drug, which is astringent or desiccant, can be considered as a good remedy for cardiac diseases such as edema, dilated cardiomyopathy, and pericarditis, which originate from tissue laxity due to excess moisture. Moreover, cardiac diseases due to weak action of myocardium or valves can